CHICAGO (AP) -- Tommy Milone pitched two-hit ball into the eighth inning and the Minnesota Twins got their first win under manager Paul Molitor, beating the White Sox 6-0 Friday in Chicago's home opener.Joe Mauer reached base four times, with an RBI single and three walks. Eduardo Escobar doubled and scored twice hours after his fiancee gave birth to a boy, and Brian Dozier homered.The Twins got some relief after getting knocked around in a three-game sweep at Detroit, while the White Sox (0-4) matched their worst start since 1995. Milone (1-0) yielded a bunt single to Micah Johnson in the third and retired the next 16 batters before Tyler Flowers chased him with a two-out double in the eighth. He struck out seven and walked two.Brian Duensing retired Johnson on a fly to left to end the eighth and worked the ninth for his first save.The game ended with Adam Eaton, who led off the ninth with a double, getting thrown out trying to score on a pop fly by Jose Abreu to the shortstop Escobar in shallow left.After going scoreless through the first 24 1-3 innings and getting pounded a combined 22-1 in the Tigers series, the Twins grabbed a 1-0 lead in the first when Mauer drove in Escobar with a single. Escobar also led off the fifth with a double and scored from third on a wild pitch by Hector Noesi (0-1) with the bases loaded.Dozier made it 3-0 in the sixth with a drive to left off Matt Albers for his first homer after hitting a career-high 23 last year. Jordan Schafer capped a three-run eighth by driving in two with a bloop single off Zach Putnam.Noesi lasted 4 2-3 innings for Chicago, allowing two runs and four hits. He struck out six but struggled with his control, walking six, throwing two wild pitches and hitting a batter.The White Sox, who were swept by defending AL champion Kansas City in their opening series, finished with three hits.